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Celiac disease is an autoimmune disorder that affects the small intestine, triggered by the consumption of gluten-containing foods. It is estimated to affect around 1% of the global population. While the most well-known symptom is digestive discomfort, there are various other signs and symptoms associated with this condition. In this comprehensive guide, we will explore the nine common symptoms of celiac disease and discuss their impact on individuals.

Digestive Symptoms:

One of the most prominent symptoms of celiac disease is digestive issues. These symptoms may include recurring abdominal pain, bloating, diarrhea, and constipation. The damage caused to the lining of the small intestine by gluten consumption leads to malabsorption of nutrients, resulting in these gastrointestinal problems. Some individuals may experience an alternating pattern of diarrhea and constipation, while others may have chronic diarrhea as their primary symptom.

Weight Loss and Malnutrition:

Unexplained weight loss can be an alarming symptom of celiac disease. When the small intestine’s lining is damaged, it fails to absorb vital nutrients from food, leading to malnutrition. Deficiencies in essential vitamins, minerals, and nutrients, such as iron, calcium, and folate, can occur. Consequently, individuals with celiac disease may experience fatigue, weakness, and a general decline in overall health.

Chronic Fatigue:

Celiac disease can cause persistent fatigue and a lack of energy. This symptom often goes unnoticed or is attributed to other factors. Fatigue can result from both malnutrition due to nutrient deficiencies and the body’s immune response to gluten consumption. It is important for individuals experiencing chronic fatigue to consider the possibility of celiac disease as a potential cause.

Dermatological Symptoms:

Skin manifestations are not uncommon in individuals with celiac disease. Dermatitis herpetiformis (DH) is a chronic skin condition characterized by itchy, blistering rashes, primarily on the elbows, knees, buttocks, and scalp. DH is linked to gluten sensitivity and shares an autoimmune response similar to celiac disease. Skin symptoms may precede or occur alongside gastrointestinal symptoms, making it important to consider celiac disease as a potential cause for unexplained skin issues.


Iron-deficiency anemia is a prevalent symptom of celiac disease. The damaged small intestine is unable to absorb iron efficiently, leading to decreased iron levels in the body. Anemia can result in fatigue, weakness, pale skin, shortness of breath, and dizziness. It is essential to investigate the underlying cause of anemia, especially in the absence of obvious explanations such as menstruation or external bleeding.

Osteoporosis and Bone Disorders:

Celiac disease can have long-term effects on bone health. Malabsorption of calcium and vitamin D, along with the inflammatory response triggered by gluten, can lead to weakened bones and osteoporosis. Individuals with celiac disease are at an increased risk of fractures and may experience joint pain, muscle cramps, and delayed healing of bone fractures. Regular screening for bone density and appropriate supplementation are crucial for managing these complications.

Neurological Symptoms:

Celiac disease can affect the nervous system, resulting in various neurological symptoms. These may include migraines, headaches, peripheral neuropathy (tingling or numbness in the extremities), balance problems, and even seizures. While the exact mechanism is not fully understood, it is believed that the autoimmune response triggered by gluten in susceptible individuals can lead to neurological complications.

Infertility and Reproductive Issues:

Celiac disease may have an impact on fertility and reproductive health, particularly in women. It can lead to menstrual irregularities, such as amenorrhea (absence of menstruation) or shortened menstrual cycles. Additionally, undiagnosed celiac disease may increase the risk of miscarriages and complications during pregnancy. Both men and women with celiac disease may experience infertility, highlighting the importance of screening for this condition when fertility issues arise.

Behavioral and Psychological Symptoms:

Some individuals with celiac disease may exhibit behavioral and psychological symptoms. These can include depression, anxiety, irritability, mood swings, and cognitive difficulties. The reasons behind these symptoms are not entirely clear, but they may be associated with nutrient deficiencies, the impact of chronic illness on mental well-being, and potential effects on neurotransmitter function.


Celiac disease is a complex autoimmune disorder with a wide range of symptoms that extend beyond digestive discomfort. While digestive issues are commonly associated with this condition, it is crucial to recognize and understand the other symptoms discussed in this comprehensive guide. Identifying and diagnosing celiac disease promptly can lead to effective management and improved quality of life for individuals affected by this condition. If you suspect you may have celiac disease, consult with a healthcare professional for proper evaluation, diagnosis, and guidance on managing the disease through a gluten-free diet and other necessary interventions.

Tatyana Dyachenko
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